[Endothelial cells analysis after intraoperative mitomycin-C adjuvant pterygium simple excision surgery: a pilot study]. / Análisis morfométrico del endotelio de la córnea tras aplicación intraoperatoria de mitomicina C en la resección simple de pterigión: un estudio piloto.

PURPOSE: To study the effects of mitomycin-C (MMC) on the corneal endothelium after pterygium surgery. METHODS: Prospective, interventional, nonrandomized, observer-masked study. Twenty patients (20 eyes) with primary pterygium underwent surgery with pterygium simple excision followed by 0.02% MMC application for 1 minute. Preoperative, 10-day, 1-month and 3-month postoperative specular microscopy were performed. Mean cell density, coefficient of variation of mean cell area and percentage of hexagonal cells were measured. RESULTS: Mean endothelial cell densities before and 3 months after surgery were 2,240.37 SD 347.92 cells/mm2 (range: 1,020 to 2,703) and 2,283.86 SD 425.13 cells/mm2 (range: 1,001 to 2,837), respectively. Mean coefficient of variation before and 3 months after surgery were 32.63 SD 4.65 (range: 22 to 48) and 33.00 SD 4.75 (range: 23 to 51), respectively. Mean percentage of hexagonal cells before and 3 months after surgery were 54.58 SD 6.60 (range: 46 to 71) and 55.26 SD 8.89 (range: 38 to 76), respectively. No statistically significant differences were found in any of the parameters studied when compared to the preoperative values. CONCLUSIONS: A single intraoperative application of 0.02% MMC for 1 minute during pterygium simple excision surgery does not seem to cause substantial changes in corneal endothelial cell density at 3 months.

Queratopatía lipoidea primaria bilateral / Primary bilateral lipid Keratopathy

Caso clínico: Mujer de 45 años que desde la infanciarefería irritación ocular y fotofobia bilateral. Enla biomicroscopía se apreciaba en ambos ojos depósitosblanco-amarillentos en estroma profundo de laperiferia media corneana. La evolución de estosdepósitos fue lentamente progresiva sin repercusiónsignificativa sobre la agudeza visual.Discusión: La configuración bilateral y simétricade los depósitos lipídicos, la ausencia de vascularizacióncorneal y de patología ocular previa, asícomo la ausencia de enfermedad del metabolismolipídico asociada apoyan el diagnóstico de queratopatíalipídica primaria en nuestro caso. La evoluciónlentamente progresiva de la enfermedad quedatambién confirmada (AU)

Case report: Observational, case report study. A45-year-old woman complained of bilateral irritationand photophobia since childhood. Slit-lampexamination revealed yellow-whitish depositsinvolving the deep stroma of the peripheral half ofthe cornea in both eyes. The evolution was slowlyprogressive with a moderate impairment of hervisual acuity.Discussion: Lipid deposits adopt symmetric andbilateral configurations; the absence of corneal vascularizationand ocular pathology as well as anylipoprotein disorder support the diagnosis of primarylipid keratopathy. The slow progressing diseaseis also confirmed(AU)